2024 Specific target organ toxicity 中文

Specific target organ toxicity 中文

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WebTarget Organ Toxicity • Adverse effects or disease states manifested in specific organs in the body. • High cardiac output = higher exposure. • Organs each have specialized tissues … Web- a high dose, selected to enable identification of target organ toxicity or other non-specific toxicity, or until limited by volume of dose. Limit doses for acute, subchronic, and chronic toxicity studies of 1000 mg/kg/day for rodents and non-rodents are considered appropriate in all cases except those discussed in the Guideline ICH M3 (R2).

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WebThe mixture is classified as a specific target organ toxicant with single exposure if at least one ingredient is classified as a Category 1 or Category 2 specific target organ toxicant … WebJul 19, 2024 · Health hazard means a chemical which poses one of the following hazardous effects: Carcinogenicity; acute toxicity (any route of exposure); aspiration hazard; … japanese brand rice cooker

Definitions of target organ and hazards of chemicals under the …

Webmay have specific reactive pathways. Hughes Principles of Environmental Toxicology 5 Target Organ Toxicity, 2 • Toxicants do not affect all organs to the same extent. • A toxicant may have several sites of action and target organs. • Multi-toxicant exposure may target the same organ. • The target organ may not be the site for storage. WebJan 16, 2024 · Specific target organ toxicity - repeat exposure (STOT-RE) means specific target organ toxicity arising from repeated exposure to a substance or mixture. This is an example of an chronic effect. Section 9 of Appendix A is devoted entirely to STOT-RE. STOT without a suffix is a general shorthand for either or both STOT-SE and/or STOT-RE WebMAM GHS - Australia H372 - Causes damage to organs through prolonged or repeated exposure [Specific target organ toxicity - repeated exposure - Category 1] ADDITIONAL LISTINGS LIST NAME AND SOURCE NOTIFICATION RESTRICTED LIST Green Science Policy Institute (GSPI) GSPI - Six Classes of Problematic Chemicals Antimicrobials japanese brand thermos

specific target organ toxicity - 英中 – Linguee词典

Specific Target Organ Toxicants - University of Arkansas

WebReproductive toxicity This hazard class includes products that may damage or are suspected of damaging fertility (the ability to conceive children) or the embryo, fetus, or offspring. Note: There is also a category that includes products that may cause harm to breast-fed children. Specific target organ toxicity – single exposure WebOct 20, 2024 · Target organ toxins are chemicals that can cause adverse effects or disease states manifested in specific organs of the body. Toxins do not affect all organs in the … lowe\u0027s chandler blvdWebReproductive toxicity No data available Specific target organ toxicity - single exposure No data available Specific target organ toxicity - repeated exposure No data available Aspiration hazard No data available 11.2 Additional Information To the best of our knowledge, the chemical, physical, and toxicological properties have not japanese brand in malaysia

"WebThe most complex path to toxicity involves more steps (Figure 3–1).First, the toxicant is delivered to its target or targets (step 1), interacting with endogenous target molecules (step 2a) or altering the environment (step 2b), triggering perturbations in cell function and/or structure (step 3), which initiate repair mechanisms at the molecular, cellular, and/or … " - Specific target organ toxicity 中文

Specific target organ toxicity 中文

CS-309-25 3511000 Health Product Declaration v2.3 Section …

WebJul 6, 2024 · Respiratory Toxicity relates to effects on the upper respiratory system (nose, pharynx, larynx, and trachea) and the lower respiratory system (bronchi, bronchioles, and … WebSpecific target organ toxicity – single exposure (see Chapter 3.8 for classification criteria) UN-2. specific Target Organ Toxicant, category 1 or 2, eurlex-diff-2024-06-20. Specific …

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WebSpecific target organ toxicity (single exposure) (STOT-SE) means specific non-lethal effects on organs or organ systems in the body following single exposure to a chemical. All … Web(e) substance-induced species-specific mechanisms of toxicity, i.e. demonstrated with reasonable certainty to be not relevant for human health, shall not justify classification. Summary of target organ toxicity induced by UV-320 after repeated exposure In the 28-day study of Hirata-Koizumi et al. (2007) females and male rats were

WebDec 7, 2016 · Target Organ Toxicity. Target organ toxins are chemicals that can cause adverse effects or disease states manifested in specific organs of the body. Toxins do … Web大量翻译例句关于"specific target organ toxicity" – 英中词典以及8百万条中文译文例句搜索。

WebSpecific target organ toxicity, repeated exposure (chapter 3.9) 1 H373 May cause damage to organs ( state all organs affected, if known) through prolonged or repeated exposure (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard) Specific target organ toxicity, repeated exposure (chapter 3.9) 2 ... WebTranslations in context of "quant à la toxicité pour certains organes cibles" in French-English from Reverso Context: En fait, les effets dont il faut tenir compte quant à la toxicité pour certains organes cibles à la suite d'une exposition unique à un danger de la catégorie 3 sont totalement différents des effets des dangers de la catégorie 1 ou 2.

WebApr 5, 2024 · Acute toxicity – Oral, Dermal, Inhalation (Category 4) Skin corrosion/irritation – Skin irritation (Category 2) Serious eye damage/eye irritation – Eye irritation (Category 2 …

WebJun 30, 2024 · First published in 1986: This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific … japanese breadcrumbs crossword clueWeb3.8.1. 3.8.1.: Definitions and general considerations. 3.8.1.1. Specific target organ toxicity ( single exposure) is defined as specific, non lethal target organ toxicity arising from a single exposure to a substance or mixture. All significant health effects that can impair function, both reversible and irreversible, immediate and/or delayed ... japanese brand sweetheart sofaWebSafeopedia Explains Specific Target Organ Toxicity (STOT) The Globally Harmonized System of Classification and Labeling of Chemicals (GHS) categorizes the specific target … japanese brand backpackWebSPECIFIC TARGET ORGAN SYSTEMIC TOXICITY (TOST) FOLLOWING A SINGLE EXPOSURE DEFINITIONS 1. Classification identifies the chemical substance as being a specific … japanese brand beauty productsWebStudy with Quizlet and memorize flashcards containing terms like Organ toxicity, Organ, Target organ toxicity (2) and more. ... *Toxins with a specific target to damage *Adverse effects or disease states manifested in specific organ in the body. Doxorubicin. Target organ toxin to the heart causing cardiomyopathy. japanese bread crumb coating crosswordWebSTOT - repeated exposure (STOT-RE) refers to the adverse, non-lethal, organ-specific health effects of a toxic substance that only manifest after multiple exposures. Category 1: Substances that produce significant toxicity in humans after repeated exposure. Category 2: Substances that are presumed to be harmful to humans after repeated exposure ... lowe\\u0027s chantillyWebTarget Organ Toxicity in Marine and Freshwater Teleosts - Feb 16 2024 Addressing the numerous gaps in current information, Target Organ Toxicology in Marine and Freshwater Teleosts is an essential resource for researchers and ... devoted to specific organs with coverage of the gill, kidney, skin, liver and gut. The companion volume, Systems ... lowe\u0027s chandler az 85224